Monday, August 13, 2012

Ground-Breaking Weight And Health Conference Set To Take ...

From The Sacramento Bee?..

?Explore. Discover. Empower.? ? Join the Obesity Action Coalition (OAC) for the Inaugural Your Weight Matters National Convention

Today, more than 93 million Americans are affected by the disease of obesity. Many of the individuals affected often find themselves struggling with the understanding of how their weight impacts their health. It is not uncommon for Americans to be exposed to dozens of ?weight-loss-focused? messages on a daily basis; however, rarely are these messages based on evidence-based and unbiased information.

In an effort to combat obesity and provide individuals with comprehensive, unbiased and evidence-based educational information on weight and its impact on health, the OAC is proud to host the Inaugural Your Weight Matters National Convention. Set to take place at the exquisite Hilton Anatole Dallas, the Convention promises to offer attendees a never-before-seen approach to weight and health education and advocacy. The Convention will feature educational sessions led by the country?s leading experts on weight and health on topics such as medically managed weight-loss, metabolic and bariatric surgery, weight bias, body image issues, childhood obesity, weight plateaus, nutrition, exercise and much more.

?There really will be something for every individual impacted by excess weight and obesity. One of the most innovative aspects of our Convention is that attendees will have the opportunity to take part in a ?Lunch with the Experts.? During this lunch, attendees will sit one-on-one with a healthcare professional and discuss specific topics, such as food addiction, intimacy issues and weight and more. We know the Convention is going to finally offer individuals what they?ve been looking for and answer all their weight and health-related questions,? said Joe Nadglowski, OAC President and CEO.

To read the full story?..Click here

Source: http://www.lensaunders.com/wp/?p=3224

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Introvert's Introduction: sing for the sun

day 224

I am now convinced I can do anything with photoshop. It took me nearly five hours to edit this, from rebuilding Aly's skirt and completely painting in her foot, to adding the clouds and airplane and other flying things. But it was totally worth it, no? I could spend the rest of my life doing this and be absolutely happy. In a few days I'll post a behind-the-scenes video from this shoot, so watch out for that!

A big thank you to Aly for modeling for me despite walking around barefoot and getting eaten by mosquitoes. And thank you for paying for my ice cream after we chased down the ice cream truck man. :)

Detail shot here. Seriously go look at it, there are little surprises.

Other than running around with Aly, Matt got to come over for a family dinner, and then he and I got to go to the arcade with Joel and Marquel! Oh, and I'm finally allowed to tell you guys this awesome news. Joel and Marquel are pregnant! I'm super excited about this because I love babies and them and fun secrets that I finally get to share. Matt and I were one of the first people they told (even before their parents, hah), but we had to keep it a secret so that they could tell other people. Marquel sent me her first ultrasound via text this morning and man oh man there's a baby inside her! I just find it completely fascinating and exciting.

But anyways, after hanging out with them, Matt and I came back to my house to play video games and card games with the family. It was a ton of fun and hopefully we'll get a few more family nights in before we leave.

I hope you all had a super fantastic day as well!

Source: http://introvertsintroduction.blogspot.com/2012/08/sing-for-sun.html

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'Theranostic' imaging offers means of killing prostate cancer cells

Monday, August 13, 2012

Experimenting with human prostate cancer cells and mice, cancer imaging experts at Johns Hopkins say they have developed a method for finding and killing malignant cells while sparing healthy ones.

The method, called theranostic imaging, targets and tracks potent drug therapies directly and only to cancer cells. It relies on binding an originally inactive form of drug chemotherapy, with an enzyme, to specific proteins on tumor cell surfaces and detecting the drug's absorption into the tumor. The binding of the highly specific drug-protein complex, or nanoplex, to the cell surface allows it to get inside the cancerous cell, where the enzyme slowly activates the tumor-killing drug.

Researchers say their findings, published in the journal American Chemical Society Nano online Aug. 6, are believed to be the first to show that chemotherapies can be precisely controlled at the molecular level to maximize their effectiveness against tumors, while also minimizing their side effects.

Senior study investigator Zaver Bhujwalla, Ph.D., a professor at the Johns Hopkins University School of Medicine and its Kimmel Cancer Center, notes that a persistent problem with current chemotherapy is that it attacks all kinds of cells and tissues, not just cancerous ones.

In the theranostic imaging experiments, overseen by Bhujwalla and study co-investigator Martin Pomper, M.D., Ph.D., investigators directed drugs only to cancer cells, specifically those with prostate-specific membrane antigen, or PSMA cell surface proteins.

"Our results show a non-invasive imaging approach to following and delivering targeted therapy to any cancer that expresses PSMA," says Bhujwalla, who also serves as director of the Johns Hopkins In Vivo Cellular and Molecular Imaging Center (ICMIC), where the theranostic imaging studies were developed.

Bhujwalla says the new technique potentially will work against any cancer in which tumors elevate production of certain cell surface proteins. Examples would include breast cancers with HER-2/neu and CXCR4 proteins, and some liver, lung and kidney cancers also known to express particular proteins. She notes that PSMA is expressed in the vessels of most solid tumors, suggesting that the nanoplex reported in the latest study could be used in general to image and treat a variety of cancers.

In their latest series of experiments, primarily in mice injected with human prostate tumor cells, Bhujwalla and the Johns Hopkins team tested their ability to track with imaging devices the delivery of anti-cancer drugs directly to tumors. Some of the tumors were comprised of cells with PSMA, while other so-called control tumors had none. Included in the drug nanoplex were small strands of RNA, cell construction acids that can be used instead to block and turn down production of a well-known enzyme, choline kinase, whose levels usually rise with tumor growth. All nanoplex components were imaged inside the tumor, in addition to dropping choline kinase production, which decreased by 80 percent within 48 hours of nanoplex absorption into cells with ample PSMA. When researchers used antibodies to block the action of PSMA, down went the level of nanoplex uptake and drug activation in cancerous cells as measured by dimming of the image.

Different concentrations of the drug nanoplex, tagged with radioactive and fluorescent molecules, were mixed in the lab with prostate cancer tissue cells, some of which had extra PSMA and others which had none. Only those cells with extra PSMA showed nanoplex uptake, as measured by image intensity, which later decreased when PSMA-blocking chemicals were added (back to levels seen in cells with almost no PSMA).

Additional experiments involving injections of three different concentrations of the drug nanoplex showed no damage to other vital mouse organs, such as the kidney and liver, nor any uptick in the mouse immune system response.

"Our theranostic imaging approach shows how the best methods of detection and treatment can be combined to form highly specialized, more potent and safer forms of chemotherapy," says Pomper, a professor at Johns Hopkins, who also serves as an associate director at ICMIC.

He says that an important goal for theranostic imaging is to move it beyond standard chemotherapy that attacks one target molecule at a time. "With theranostic imaging, we can attack multiple tumor targets, making it harder for the tumor to evade drug treatment," says Pomper, who is already working with colleagues at Johns Hopkins to identify other molecular targets.

###

Johns Hopkins Medicine: http://www.hopkinsmedicine.org

Thanks to Johns Hopkins Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 18 time(s).

Source: http://www.labspaces.net/122485/_Theranostic__imaging_offers_means_of_killing_prostate_cancer_cells

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Sunday, August 12, 2012

International Business Strategy

International Business Strategy This textbook shows how the key concepts from business strategy literature can be applied to create successful global business. How can you best extend your knowledge of how multinational enterprises (MNEs) function? What does globalization mean...

More information

Source: http://www.workyourwayupfilm.com/international-business-strategy/

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What's next for golden US women's team?

Behind The Scenes: U.S. Women's Soccer Gold Medal Ceremony

LONDON (AP) ? They got a personal shout-out from President Barack Obama, partied with a few of the NBA players and actor Tim Robbins and stayed up into the wee hours of the morning celebrating.

Exhausted but elated, the U.S. women's soccer team is taking a few days to revel in its latest Olympic gold medals ? to say nothing of the star treatment that goes with them ? before heading back home.

To what, the players don't really know. The next major tournament is three years away, and options to play at home are limited with WPS defunct and plans for a new league still in flux.

"This has been our focus, our attention for the last few years now," Heather O'Reilly said Friday. "There's a little bit of uncertainty right now."

The Americans won their third straight Olympic title, and fourth overall, Thursday night, beating Japan 2-1 in a rematch of last year's World Cup final and avenging the most painful loss in their history. The victory was another showcase of their grit and resilience, qualities that have endeared them to folks back home, as well as a testament to their depth.

Sure, Hope Solo, Abby Wambach and Carli Lloyd have been mainstays of the team for years now. But youngsters Tobin Heath, Kelley O'Hara and Becky Sauerbrunn played key roles in the game ? the whole tournament, really ? and there's more where they came from. Just as they've been doing since the days of Mia Hamm, Julie Foudy, Michelle Akers and Brandi Chastain, the Americans simply retool when big-time players step away or slow down.

But that will be harder and harder as the rest of the world catches up to the Americans. Other countries are pumping resources into their women's program, and the results were evident both at the Olympics and last year's World Cup final. After losing its first 25 games to the United States, Japan is 1-2-1 against the U.S. since the World Cup final, and the teams' rivalry has the potential of being even bigger than those with Germany, Sweden, maybe even Brazil.

After reaching the semifinals in only its second World Cup appearance last summer, France played in the Olympic bronze medal game, losing to Canada.

"Having a professional league is going to be really crucial for the continued development of our team so we not only can stay on top, but we can keep pushing the envelope," Wambach said. "All the other leagues in the world are doing that. That's why their national teams are even better, because these players are getting more experienced. These players are playing 90-minute games at high levels. If you get a number of players doing that, game in and game out, they're bound to get better."

There clearly is interest in the women's team. Most of the country is on a first-name basis with Abby, Hope and Alex, and their games in both the World Cup and Olympics have been big draws ? both in the stands and in front of the T.V. sets. The final Thursday was such a big deal it drew an Olympic-record 80,203, and Wambach said some of the NBA players passed up seats in a suite to get closer to the field.

But translating that interest into a financially viable league has been trickier than a bicycle kick. The WPS folded this year, the second women's professional soccer league to do so in the last decade.

While some players have talked about playing overseas, U.S. Soccer Federation President Sunil Gulati said this week he'd prefer they stay at home. Among the possibilities are upgrading one or more of the various semipro leagues in the U.S., or having an extended residency program for the U.S. national team, with a schedule of 25-30 games per year.

Whatever the decision, the players have to get playing time. Or the gold medals that have become practically a birthright for the Americans might start going to other countries.

"If I sit and think about it, there's a little bitterness. More than a little bitterness," Solo said. "It's the times we live in, there should be opportunities for women. We have so many young players coming out of college and they have nowhere to go play. They're not quite good enough to make the national team ? but they could be in the next couple of years. But the opportunities aren't there for them."

And the Americans will likely need to dip into that up-and-coming talent pool before the 2015 World Cup, which will be in Canada. Defender Heather Mitts has already said she is retiring. Captain Christie Rampone has two small girls and is 37 ? though she plays far younger than that ? and has said she needs time to decide whether to keep playing or not. Midfielder Shannon Boxx is 35.

Even Wambach is not a given. Though she craves a World Cup title and has said she intends to play through the 2015 tournament, she turned 32 this summer and her body has begun showing signs of the wear and tear from her fearless playing style.

"I can only be positive that there is a spot for players to play in the future," Solo said. "In the near future."

In the meantime, the Americans will do a "victory tour," beginning next month. The first two games have already been announced: Sept. 1 against Costa Rica and Sept. 16 against Australia. Some well-deserved downtime will come after that. O'Reilly and her husband never did take a honeymoon after their wedding last fall, and Lloyd is craving some beach time.

But at some point, the Americans will have to figure out what comes next.

It might present an even bigger challenge than Japan did.

"We haven't really thought too far in advance," Lloyd said. "There's a lot of missing parts, whether there's a league ? we just heard bits and pieces about a league coming back. But we're going to go after it. I want to win a world championship before my career is over. So that's the next thing."

Hope Solo, Carli Lloyd, Alex Morgan and Abby Wambach talk to Bob Costas about the women's final match and winning the gold.

? 2012 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.nbcolympics.com/news-blogs/soccer/u-s-womens-soccer-team-wins-gold-but-whats-next.html

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Friday, August 10, 2012

A look at telecom-industry subscriber reports

Telecommunications companies have begun releasing their earnings reports for the latest quarter. Here is a summary of reports for selected telecommunications companies and what they reveal about their own and the industry's prospects.

? July 19: Verizon Communications Inc. says its wireless unit gained a net 1.2 million subscribers ? a strong result in an industry where subscriber gains have tapered off now that nearly everyone has a cellphone. Of the new subscribers, 888,000 were on contract-based plans, which are the most lucrative. Verizon Wireless has 94.2 million retail subscribers. The profit margin at Verizon Wireless was the highest ever, as average monthly fees for contract-signing subscribers rose 3.7 percent to $56.13. Verizon is benefiting from the growing popularity of smartphones, which come with data fees.

? July 24: AT&T Inc. says it saw declining smartphone sales, leading to the best profitability ever in its wireless arm as it saved on phone subsidies. It activated 5.1 million smartphones in its latest quarter, down from 5.5 million a year ago. Much of the decline came because AT&T subscribers are holding on to their phones longer. AT&T added a net 320,000 subscribers on contract-based plans in the quarter. However, more than half of the new subscribers were tablet users, who pay less than smartphone users.

? July 26: Sprint Nextel Corp. reports it was successful in persuading smartphone subscribers to pay up for "unlimited data" service, and its service revenue zoomed, beating estimates. Sprint activated 1.5 million iPhones in the quarter, the same number as in the first quarter. By contrast, AT&T and Verizon saw a drop in iPhone activations as the excitement around the latest model, the iPhone 4S, cooled. Sprint is the only one of the four national wireless carriers that still offers unlimited data service, though it offers relatively slow data speeds.

MetroPCS Communications Inc., a provider of contract-free service, says it lost about 186,000 subscribers to end the quarter at 9.3 million.

? July 31: Frontier Communications Corp. ended the quarter with 3.1 million residential lines, down about 67,000 from the previous quarter.

? Aug. 1: Comcast Corp. says it added 158,000 phone customers to end the quarter with 9.7 million.

? Aug. 2: Time Warner Cable Inc. says it added 45,000 residential phone customers to end with 5 million.

? Aug. 3: U.S. Cellular Corp., a unit of Telephone Data and Systems Inc., lost a record 48,000 subscribers from contract-based plans in the quarter. That was partly offset by a gain of 20,000 contract-free customers. The company ended the quarter with 5.8 million customers, making it the seventh-largest cellphone company in the country.

? Monday: Leap Wireless International Inc., the nation's sixth-largest cellphone carrier and operator of the Cricket brand, says it lost 289,000 customers during the quarter to end with 5.9 million.

? Wednesday: CenturyLink Inc. says it had 14.1 million access lines, a loss of 234,000 during the quarter.

? Thursday: T-Mobile USA, a unit of Deutsche Telekom AG, says it lost a net 205,000 subscribers in the second quarter, a record for the period. Among phone subscribers under contract, it lost 557,000 subscribers, also the highest number of the second quarter.

Windstream Corp. says it has 2.9 million phone lines. It lost about 29,000 during the quarter.

Source: http://news.yahoo.com/look-telecom-industry-subscriber-reports-230208847.html

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